- 1. DNA vaccine candidate encoding SARS-CoV-2 spike proteins elicited potent humoral and Th1 cell-mediated immune responses in mice ...
- (Covid)
- ... S antigen is more potent than the truncated spike (S1 or S2) in inducing of neutralizing antibody and robust T cell responses. Figures Citation: Prompetchara ...
- Created on 22 March 2021
- 2. Immunization stress-related responses presenting as psychogenic non-epileptic seizures following HPV vaccination in Rio Branco, Brazil. ...
- (Vaccine Adverse Event Denialism)
- ... doi: 10.1038/nrneurol.2011.24. Epub 2011 Mar 8.PMID: 21386814 Review. Source: https://www.semanticscholar.org/paper/Immunization-stress-related-responses-presenting-as-Marchetti-Gallucci-Neto/6edd90d37ac826cec52f8f57f327b4b4af7a55a8 ...
- Created on 07 October 2020
- 3. The potential role of Th17 immune responses in coronavirus immunopathology and vaccine-induced immune enhancement ...
- (Covid Vaccine Induced Myocarditis)
- Increasing evidence points to host Th17 inflammatory responses as contributing to the severe lung pathology and mortality of lower respiratory tract infections from coronaviruses. This includes host inflammatory ...
- Created on 17 April 2020
- 4. The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT-TCF pathway responses in human cancer ...
- (Ivermectin)
- ... complex, for instance through APC mutation, phosphorylation of β-CATENIN at C-terminal sites is required for the full activation of WNT-TCF signaling and the ensuing WNT-TCF responses in cancer. Attempts ...
- Created on 20 August 2014
- 5. Ashley Youth Detention Centre guards forced child to perform sexual acts to get his medication, inquiry hears
- (Youth Detention)
- ... significantly since 2015, there continue to be young people detained there. "The commission has heard evidence in the lead-up to these hearings about past and recent processes and responses that are of conc ...
- Created on 04 August 2023
- 6. Ruby
- (Paedophiles Given Custody)
- ... Practice Review (CSPR) undertaken by the Leeds Safeguarding Children Partnership. The purpose of a CSPR is to learn lessons and improve future responses to situations whereby a child has experienced serious ...
- Created on 24 June 2023
- 7. SARS-CoV-2 vaccination can elicit a CD8 T-cell dominant hepatitis
- (Covid Vaccine Issues)
- ... of SARS-CoV-2-specific CD8 T cells, indicating that post-COVID19 vaccination hepatitis involves vaccination-elicited antigen-specific immune responses with distinct histological features compared to bona ...
- Created on 20 April 2022
- 8. Covid-19: A vaccine candidate using a lentiviral vector
- (Chinavirus and other Bioweapons)
- This vaccine candidate for the SARS-CoV-2 virus, designed for nasal administration, demonstrated intense protection and extremely high production of antibodies and cytotoxic cell responses in preclinical ...
- Created on 31 March 2022
- 9. Ivermectin for COVID-19: real-time meta analysis of 78 studies
- (Ivermectin)
- ... ey cells (the only choice at the time of the experiments), which lack adaptive immune responses and do not produce interferon. Authors also note that ivermectin accumulates in lung and other tissues, t ...
- Created on 05 February 2022
- 10. The mechanisms of action of ivermectin against SARS-CoV-2—an extensive review
- (Ivermectin)
- ... responses. The entry of SARS-CoV-2 into the host cell is mediated by the binding of the S1 subunit of its S protein (receptor binding domain) to the angiotensin-converting enzyme 2 (ACE-2) receptors present ...
- Created on 21 December 2021
- 11. Pathways Case Record: Covid-19 Vaccine-Associated Hyperinflammation
- (Vaccine Injuries)
- ... e, characterization of immune cell populations via flow cytometry or single-cell RNAseq may provide insight into the cells driving her inflammatory response. Humoral immune responses measured by systems serol ...
- Created on 14 December 2021
- 12. Melatonin: its possible role in the management of viral infections - a brief review
- (Covid Health Resources)
- ... has the capability to regulate leukocyte function and contributes to the control of inflammation in tissues acting as both an activator and inhibitor of the inflammatory and immune responses [1, 2, 24, 25]. ...
- Created on 12 November 2021
- 13. COVID-19 vaccine design: the Janus face of immune enhancement
- (Covid Vaccine Issues)
- ... immunopathology prompted concerns that T helper 2 (TH2)-type immune responses might be responsible, sometimes directed to virus-induced expression of the SARS nucleocapsid (N) protein. However, our in-depth ...
- Created on 12 November 2021
- 14. Prior immunization with SARS nucleocapsid protein causes severe pneumonia in mice infected with SARS
- (Covid Vaccine Research)
- Abstract The details of the mechanism by which severe acute respiratory syndrome-associated coronavirus (SARS-CoV) causes severe pneumonia are unclear. We investigated the immune responses ...
- Created on 05 November 2021
- 15. A Report on Myocarditis Adverse Events in the U.S. Vaccine Adverse Events Reporting System (VAERS) in Association with COVID-19 Injectable Biological Products
- (Covid Vaccine Induced Myocarditis)
- Following the global rollout and administration of the Pfizer Inc./BioNTech BNT162b2 and Moderna mRNA-1273 vaccines on December 17, 2020, in the United States, and of the Janssen Ad26.COV2.S product ...
- Created on 01 November 2021
- 16. Ivermectin for prevention and treatment of COVID-19 infection: A systematic review, meta-analysis, and trial sequential analysis to inform clinical guidance
- (Ivermectin)
- ... of action being the blocking of the nuclear import of viral proteins14,15 that suppress normal immune responses. However, the necessary cell culture EC50 may not be achievable in vivo.16 Other conjectured ...
- Created on 22 October 2021
- 17. Use of lentiviral vectors in vaccination
- (HIV based Lentiviral Vectors)
- ... dendritic cells are required for the activation of helper-dependent CD8 T cell responses to a model antigen after cutaneous vaccination with lentiviral vectors. Goold HD, Escors D, Conlan TJ, Chakraverty ...
- Created on 11 October 2021
- 18. Why are we vaccinating children against COVID-19?
- (Covid and Children)
- ... published in NEJM in December 2020 [34] summarized the Phase 1 results. The focus was on local and systemic adverse events and efficacy metrics (antibody responses). The only metrics other than these reporte ...
- Created on 11 October 2021
- 19. Potential challenges for Coronavirus (SARS-CoV-2) vaccines under trial
- (Coronavirus Vaccines Leads to Pulmonary and Lung Immunopathology)
- ... various recently published articles concerning the potential danger of suboptimal antibody responses or ADE of SARS-CoV-2, providing an insightful discussion (46–49). Conclusion: An Integrated Approach ...
- Created on 29 September 2021
- 20. Ivermectin, a potential anticancer drug derived from an antiparasitic drug
- (Ivermectin)
- ... thway responses in human cancer. EMBO Mol Med. 2014;6(10):1263–1278. doi: 10.15252/emmm.201404084. [PMC free article] [PubMed] [CrossRef] [Google Scholar] 42. Yang J.D., Hainaut P., Gores G.J., Amad ...
- Created on 21 September 2021
- 21. Nano-Enabled COVID-19 Vaccines: Meeting the Challenges of Durable Antibody Plus Cellular Immunity and Immune Escape
- (Covid Research)
- ... vaccine development. Figure 1 SARS-CoV-2 components for generating protective antiviral immune responses. These include the spike or S glycoprotein, membrane or M protein, envelope or E protein, ...
- Created on 14 September 2021
- 22. Vaccines and allergic reactions: The past, the current COVID‐19 pandemic, and future perspectives
- (Uncategorised)
- ... ic health and help to reduce the risk of disease across the entire population. Despite early reports of waning of antibody responses over 20 days following SARS‐CoV2 infection, evidence is now accumul ...
- Created on 14 September 2021
- 23. Why are we vaccinating children against COVID-19?
- (Covid)
- ... responses). The only metrics other than these reported were transiently decreased lymphocyte counts. We view this level of reporting as poor safety science for the following reasons. Before the clinica ...
- Created on 14 September 2021
- 24. Mass psychogenic illness following tetanus-diphtheria toxoid vaccination in Jordan
- (Vaccine Adverse Event Denialism)
- ... the literature showed, however, that this mass reaction was similar in many ways to previous outbreaks, even though the underlying causes varied. There are about 200 published accounts of mass response ...
- Created on 08 September 2021
- 25. Family Financial Disclosures Form for Covid-19 Injections
- (Ivermectin)
- ... polymer—synthetic and nondegradable—associated with adverse immune responses. Moderna has acknowledged that the LNPs “could lead to significant adverse events,”5 and FDA has identified PEG as the likely ...
- Created on 01 August 2021
- 26. Prescription, over-the-counter (OTC), herbal, and other treatments and preventive uses for COVID-19
- (Covid Research)
- ... among Italian people during the COVID-19 pandemic: immediate psychological responses and associated factors. Int J Environ Res Publ Health. 2020;17(9):3165. [PMC free article] [PubMed] [Google Scholar] ...
- Created on 28 June 2021
- 27. Halt covid vaccine, prominent scientist tells CDC
- (Covid and Scientists)
- ... experience in analyzing the molecular profile of pharmacologic responses. Her expertise centers on evaluating the complex dynamics of toxicity, such as toxicant pharmacology, exposure route, host metabolism, ...
- Created on 23 April 2021
- 28. Review of the emerging evidence demonstrating the efficacy of Ivermectin in the prophylaxis and treatment of COVID-19
- (Ivermectin)
- Background: After COVID-19 emerged on U.S shores, providers began reviewing the emerging basic science, translational, and clinical data to identify potentially effective treatment options. In addition, ...
- Created on 22 April 2021
- 29. Review of the emerging evidence demonstrating the efficacy of Ivermectin in the prophylaxis and treatment of Covid-19
- (Ivermectin)
- Conclusions: Meta-analyses based on 18 randomized controlled treatment trials of ivermectin in COVID-19 have found large, statistically significant reductions in mortality, time to clinical recovery, ...
- Created on 22 April 2021
- 30. A Proteome-Wide Immunoinformatics Tool to Accelerate T-Cell Epitope Discovery and Vaccine Design in the Context of Emerging Infectious Diseases: An Ethnicity-Oriented Approach
- (HIV based Lentiviral Vectors)
- ... system by determining the peptide repertoire displayed to the T-cell compartment. Genetic polymorphisms of the HLA system thus confer a strong variability in vaccine-induced immune responses and may ...
- Created on 26 February 2021
- 31. Multisystem inflammatory syndrome in children and adults (MIS-C/A): Case definition & guidelines for data collection, analysis, and presentation of immunization safety data
- (Multisystem Inflammatory Syndrome in Children (MIS‐C))
- Abstract This is a Brighton Collaboration Case Definition of the term “Multisystem Inflammatory Syndrome in Children and Adults (MIS-C/A)” to be utilized in the evaluation of adverse events following ...
- Created on 25 February 2021
- 32. Viral Vectors for COVID-19 Vaccine Development
- (HIV based Lentiviral Vectors)
- ... delivery of RNA as COVID-19 vaccines. Several adenovirus-based vaccine candidates have elicited strong immune responses in immunized animals and protection against challenges in mice and primates has been ...
- Created on 13 February 2021
- 33. The amendment threatening to derail the domestic abuse bill
- (Domestic Violence)
- ... from men who they know are dangerous. The objective of this proposed legislation is to better protect and support victims of domestic abuse and transform the responses of criminal, civil, and family ...
- Created on 04 February 2021
- 34. Ivermectin presents effective and selective antileishmanial activity
- (Ivermectin)
- ... as well as immunological assays, based on the evaluations of cellular and humoral responses, were performed after euthanasia of infected mice, one and 15 days post-therapy. Section snippet ...
- Created on 01 February 2021
- 35. Antivirals that target the host IMPα/β1-virus interface
- (Anti-Viral Research)
- ... rescued 70% of mice [15], concomitant with reduced inflammatory cytokine responses (tumour necrosis factor α, IL-6, -10, and -12) [15]. Efficacy was also seen in AG129 mice for ZIKV infection, where 4-HPR at ...
- Created on 31 January 2021
- 36. COVID-Vaccinations: Why it matters to know the real effectiveness
- (Covid)
- As argued in previous responses [1][2][3], the current COVID vaccines' supposed effectiveness of 95% may be a substantial overestimation. Even so, pretending such effectiveness may bring a placebo ...
- Created on 21 December 2020
- 37. Development of cell-based pseudovirus entry assay to identify potential viral entry inhibitors and neutralizing antibodies against SARS-CoV-2
- (HIV based Lentiviral Vectors)
- ... g, et al. Antibody responses to SARS-CoV-2 in patients with COVID-19 Nat Med (2020), 10.1038/s41591-020-0897-1 View PDF Google Scholar 9 R.I. Connor, B.K. Chen, S. Choe, N.R. Landa ...
- Created on 04 December 2020
- 38. Facemasks in the COVID-19 era: A health hypothesis
- (Covid and Face Masks)
- ... olar] 67. Sapolsky R.M., Romero L.M., Munck A.U. How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr Rev. 2000;21:55–89. [PubMed] [ ...
- Created on 22 November 2020
- 39. Potential Challenges for Coronavirus (SARS-CoV-2) Vaccines Under Trial
- (Covid Vaccine Issues)
- ... (45). There have been various recently published articles concerning the potential danger of suboptimal antibody responses or ADE of SARS-CoV-2, providing an insightful discussion (46–49). Go to: ...
- Created on 29 September 2020
- 40. Journalism's Gates keepers
- (Covid Financial Conflicts of Interest )
- ... Charles Piller, the lead reporter on the series, says he made strenuous efforts to get responses from the Gates Foundation during the investigation. “For the most part they were unwilling to engage ...
- Created on 21 August 2020
- 41. Journalism’s Gates keepers
- (BMGF)
- ... chocolate companies linked to child labor. Charles Piller, the lead reporter on the series, says he made strenuous efforts to get responses from the Gates Foundation during the investigation. “For the ...
- Created on 21 August 2020
- 42. Coronavirus vaccine-associated lung immunopathology-what is the significance?
- (Covid Vaccine Induced Myocarditis)
- ... immune responses that coordinately drive the production and recruitment of eosinophils [6]. Because the immunopathology seen in experimental SARS and MERS coronavirus-related VAERD models was also eosinophilic, ...
- Created on 26 June 2020
- 43. Coronavirus vaccine-associated lung immunopathology-what is the significance?
- (Coronavirus Vaccines Leads to Pulmonary and Lung Immunopathology)
- ... responses that coordinately drive the production and recruitment of eosinophils [6]. Because the immunopathology seen in experimental SARS and MERS coronavirus-related VAERD models was also eosinophilic, ...
- Created on 26 June 2020
- 44. Strategies to prevent SARS-CoV-2-Mediated Eosinophilic Disease in Association with COVID-19 Vaccination and Infection
- (Covid Vaccine Issues)
- ... is the possibility that SARS-CoV-2 vaccines might cause a similar vaccine-associated immunopathology. Go to: Immune Responses in Association with Coronavirus Vaccination The most promising strateg ...
- Created on 16 June 2020
- 45. Symptomatic Protective Action of Glycyrrhizin (Licorice) in COVID-19 Infection?
- (Covid Health Resources)
- ... PubMed Abstract | CrossRef Full Text | Google Scholar 40. Lai S, Wu G, Jiang Z. Glycyrrhizin treatment facilitates extinction of conditioned fear responses after a single prolonged stress exposure i ...
- Created on 28 May 2020
- 46. Did the Oxford Covid vaccine work in monkeys? Not really
- (Covid Research)
- ... for eliciting protective responses for protein coding genes of other viruses, in fact better than many others. This then raises the question of whether vaccine strategies based on the delivery of viral ...
- Created on 16 May 2020
- 47. South Australia’s Chief Executive Cathy Taylor should be stood down
- (Uncategorised)
- ... – including the response to the Queensland Child Protection Commission of Inquiry 2013, and worked on the Bryce Taskforce on Responses to Domestic and Family Violence of 2015. She has also led legislative ...
- Created on 13 May 2020
- 48. All the Attorney-General’s Men – Corrupt VCAT Show Trial J134/2011 (Part 3)
- (Uncategorised)
- ... Smithers, Mr Bowman and Mr Garde’s signed sealed and delivered resignation letters forthwith. I ask that VCAT state its responses clearly (verbally and then in writing) to each of the first of points ...
- Created on 10 May 2020
- 49. We have a right to expect government to do what markets cannot: social and economic protection for all of us
- (Australia)
- ... physically, mentally, socially, economically. Not only from the virus itself but from some of the social and political responses to it. From First Nations people experiencing homelessness being issued ...
- Created on 02 May 2020
- 50. Royal Commission into Institutional Responses to Child Sex Abuse ...
- (Tags)
- Royal Commission into Institutional Responses to Child Sex Abuse ...
- Created on 28 February 2016